Tariflox Oz

Ofloxacin: It is active after oral administration. It inhibits bacterial DNA replication by blocking DNA topo-isomerases, in particular DNA gyrase. Omidazole: After passive absorption inte bacterium cell, the nitro group of Omidazole is reduced to amine group by ferredoxin type redox system. The formation of redox intermediate intracellular metabolites is believed to be the key component of microorganism killing for Omnidazole. The mechanism of action is similar in protozoa.

Microbiology: Microbiclogical results indicate that the following pathogens may be regarded as sensitive: Staphylococcus aureus (including methicillin resistant staphylococci), Staphylococcus epidermidis, Neisseria species, Escherichia coli, Citrobacter, Klebsiella, Enterobacter, Hafnia, Proteus (indole- negative and indole-positive strains), Haemophilus influenzae, Chlamydiae, Legionella, Gardnerella. Variable sensitivity is shown by Streptococci, Serratia marcescens, Pseudomonas aeruginosa and Mycoplasmas. Anaerobic bacteria (e.g. Fusobacterium species, Bacteroides species, Eubacterium species, Peptococci, Peptostreptococci) are normally resistant. Ofloxacin is not active against Treponema pallidum.

Pharmacokinetics: Ofloxacin: Ofloxacin is almost completely absorbed after oral administration. Maximal blood levels occur 1-3 hours after dosing and the elimination half-life is 4-6 hours. Ofloxacin is primarily excreted unchanged in the urine. In renal insufficiency the dose should be reduced.

Ornidazole: Ornidazole is readily absorbed from the GIT and peak plasma concentrations of about 30 meg/ml are achieved within 2 hours of a single dose of 1.5 g. Food does not affect extent but rate of absorption of Ornidazole. Ornidazole is less than 15% bound to plasma proteins. It is widely distributed in body tissues and fluids, including cerebrospinal fluid. Antibacterial concentrations are achieved in vaginal secretions, amniotic fluid, appendix and intestinal tissues. More than 90% of Ornidazole dose is metabolized in liver. The metabolites are active and have same activity against anaerobic bacteria as the Ornidazole.

The elimination half-life (t1/2) of Ornidazole is 12-14 hours. It is excreted in the urine, mainly as conjugates and metabolites and to a lesser extent in the feces. Biliary excretion may be important in the elimination of Ornidazole and its metabolites.

ব্যবহার

Tariflox Oz is a combination medicine which can be used to treat infections caused by bacteria and parasites. It works by killing and stopping the growth of the bacteria and parasites causing the infection. This medicine usually makes you feel better quite quickly. However, you should continue taking it as long as it is prescribed even if you feel better, to make sure that all bacteria and parasites are killed and do not become resistant.

Ofloxacin works by preventing the bacterial cells from dividing and repairing, thereby killing the bacteria. Ornidazole kills parasites and anaerobic bacteria that cause infections by damaging their DNA. Together, they treat your infection effectively.

Tariflox Oz এর দাম কত? Tariflox Oz এর দাম

Tariflox Oz in bangla
বাণিজ্যিক নাম	Tariflox Oz
জেনেরিক	Ofloxacin + Ornidazole
ধরণ	Tablet, Suspension
পরিমাপ	200mg,
দাম
চিকিৎসাগত শ্রেণি
উৎপাদনকারী	Cipla Gx, Cipla Limited
উপলভ্য দেশ	India
সর্বশেষ সম্পাদনা	January 7, 2025 at 1:49 am

খাওয়ার নিয়ম / ব্যবহারের নিয়ম

Tariflox Oz খাওয়ার নিয়ম / ব্যবহারের নিয়ম

The duration of treatment depends upon the type & severity of the infection. Tablet & Infusion (Adults & children over 12 years of age). Tablet: One tablet of Tariflox Oz is recommended as twice daily. Infusion: 100 ml twice daily. Oral suspension: 5ml twice daily or as directed by the physician. Shake well before use.

পার্শ্বপ্রতিক্রিয়া

This medicine causes side effects such as:

Abdominal Pain
White Patches In The Mouth Or On The Tongue
Joint Pain
Black Or Tarry Stools
Fever With Chills
Chest Tightness
Running Nose
Sneezing
Memory Impairment
Nervousness
Agitation
Disorientation

সতর্কতা

মিথস্ক্রিয়া

Ofloxacin: Co-administered magnesium/aluminium antacids, sucralfate or iron preparations can feduce absorption. Therefore, Ofloxacin should be taken 2 hours before such preparations. Prolongation of bleeding time has been reported during concomitant administration of Ofloxacin and anticoagulants. There may be a further lowering of the cerebral seizure threshold when quinolones are given concurrently with other drugs which lower the seizure threshold, e.g. Theophylline, NSAIDs. However Ofloxacin is not thought to cause a pharmacokinetic interaction with theophylline, unlike some other fluorcquinolones. Ofloxacin may cause a slight increase in serum concentrations of glibenclamide administered concurrently; patients treated with this combination should be closely monitored. With high doses of quinolones, impairment of excretion and an increase in serum levels may occur when co-administered with other drugs that undergo renal tubular secretion (e.g. probenecid, cimetidine, frusemide and methotrexate).

Determination of opiates or porphyrins in urine may give false-positive results during treatment with Ofloxacin. Ornidazole: Alcohol intolerance: Unlike other nitro-imidazoles, Ornidazole does not inhibit enzyme aldehyde dehydrogenase. No disulfiram like reaction has been Teported on consumption of alcohol. However, as is the case with all imidazoles, this drug should be avoided in concomittance with alcohol usage. No clinically relevant interactions were seen with food.

গর্ভাবস্থাকালীন ব্যবহার

Pregnancy: No controlled studies of effect of the drug on pregnant women are available, Oflodazole should be prescribed to pregnant women only if the potential benefit to the mother outweighs potential risk to the foetus.

Lactation: In lactating females, a single oral 200 mg dose of Ofloxacin resulted in concentrations of Ofloxacin in milk that were similar to those found in plasma. Because of the potential for serious adverse reactions from Oflodazole in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

বৈপরীত্য

অতিরিক্ত সতর্কতা

Administration of antibiotics, especially of prolonged use, may lead to proliferation of resistant micro-organisms. The patient's condition must therefore be checked at regular intervals. If a secondary infection occurs, appropriate measures Must be taken.

Ofloxacin: Patients being treated with Ofloxacin should not expose themselves unnecessarily to strong sunlight and should avoid UV rays (sun lamps, solaria).

Caution is recommended if the drug is to be used in psychotic patients or in patients with a history of psychiatric disease.

Ornidazole: Regular laboratory tests and clinical control are indicated in case of use of high Ornidazole doses or if duration of therapy exceeds 10 days.

Blood disorders: Leukocyte counts should be checked before and after start of therapy (especially in repeat therapy), in patients with history of blood discrders.

CNS: Severe diseases of central and peripheral nervous system may get aggravated on Ornidazole therapy. Treatment should be discontinued in case of onset of peripheral neuropathy, ataxia, vertigo or confusion.

Candidiasis: Ornidazole therapy may aggravate existing candidiasis. Necessary precautions should be taken.

তীব্র ওভারডোজ

Ofloxacin: The most important signs to be expected following acute over dosage are CNS symptoms such as confusion, dizziness, impairment of consciousness and convulsive seizures as well as gastrointestinal reactions such as nausea and mucosal erosions.

In the case of overdose steps to remove any unabsorbed Ofloxacin e.g. gastric lavage, administration of adsorbents and sodium sulphate, if possible during the first 30 minutes, are recommended; antacids are recommended for protection of the gastric mucosa.

Elimination of Ofloxacin may be increased by forced diuresis. In case of over dosage, the patient should be observed carefully and symptomatic treatment should be given. The stomach should be emptied by gastric lavage or vomiting. All the supportive measures and hydration should be maintained. In case of convulsions, intravenous diazepam is recommended.

Ornidazole: In cases of over dosage of Ornidazole the symptoms mentioned under adverse reaction occur in more severe form. No specific antidote is known. The administration of diazepam is recommended if cramps occur.