Vonocab Trio 40 mg+2000 mg+1000 mg Tablet
Each Vonokit blister strip contains-
One Vonoprazan 20 mg tablet (as Vonoprazan Fumarate INN)
Two Amoxicillin 500 mg capsules (as Amoxicillin Trihydrate BP)
One Clarithromycin 500 mg tablet (as Clarithromycin USP)
Each Vonocab Trio blister strip contains-
Two Vonoprazan 20 mg tablet (as Vonoprazan Fumarate INN)
Four Amoxicillin 500 mg capsules (as Amoxicillin Trihydrate BP)
Two Clarithromycin 500 mg tablet (as Clarithromycin USP)
Each Vonolend kit contains-
Two Vonoprazan 20 mg Tablets (Each film coated tablet contains Vonoprazan Fumarate INN equivalent to Vonoprazan 20 mg)
Four Amoxicillin 500 mg Capsules (Each capsule contains Amoxicillin Trihydrate BP equivalent to Amoxicillin 500 mg)
Two Clarithromycin 500 mg Tablets (Each film coated tablet contains Clarithromycin USP 500 mg
Each Helicon V kit contains-
One Vonoprazan INN 20 mg Tablet
Two Amoxicillin BP 500 mg Capsules
One Clarithromycin USP 500 mg Tablet
ব্যবহার
Vonocab Trio 40 mg+2000 mg+1000 mg Tablet এর কাজ
The standard triple therapy regimen is indicated in the eradication of H. pylori in active chronic gastritis, duodenal and gastric ulcers.
Vonocab Trio 40 mg+2000 mg+1000 mg Tablet এর দাম কত? Vonocab Trio 40 mg+2000 mg+1000 mg Tablet এর দাম
খাওয়ার নিয়ম / ব্যবহারের নিয়ম
Vonocab Trio 40 mg+2000 mg+1000 mg Tablet খাওয়ার নিয়ম / ব্যবহারের নিয়ম
The recommended dosage regimen is-
Vonoprazan 20 mg
Amoxicillin 1000 mg
Clarithromycin 500 mg
Each given twice daily (morning and evening, 12 hours apart), with or without food, for 14 days.Geriatrics: The standard triple therapy regimen increased risk of torsade de pointes due to the clarithromycin component.Renal Impairment: Avoid use in severe renal impairment.Hepatic Impairment: Avoid use in moderate and severe hepatic impairment.
পার্শ্বপ্রতিক্রিয়া
Most common adverse reactions (>2%) were dysgeusia, diarrhea, vulvovaginal candidiasis, headache, abdominal pain, hypertension and nasopharyngitis.
সতর্কতা
Hypersensitivity Reactions: Serious and occasionally fatal reactions (e.g., anaphylaxis) have been reported with components of this triple pack. If hypersensitivity reactions occur, discontinue and institute immediate therapy (e.g., anaphylaxis management).Severe Cutaneous Adverse Reactions (SCAR): Discontinue this pack at the first signs or symptoms of SCAR or other signs of hypersensitivity and consider further evaluation.Clostridioides difficile-associated diarrhea (CDAD): Evaluate if diarrhea occurs with this pack and Due to the Clarithromycin Component:QT Prolongation: Avoid this pack in patients with known QT prolongation or receiving drugs known to prolong the QT interval, ventricular arrhythmia (torsades de pointes), hypokalemia/hypomagnesemia, significant bradycardia, or taking Class IA or III antiarrhythmics.Hepatotoxicity: Discontinue if signs and symptoms of hepatitis occur with this pack.Serious adverse reactions due to concomitant use with other drugs: Serious adverse reactions can occur with this pack due to drug interactions of clarithromycin with colchicine, some lipid lowering agents, some calcium channel blockers, and other drugs.Embryo-Fetal Toxicity: Based on the findings from animal studies and human observational studies in pregnant women treated with clarithromycin, this pack is not recommended for use in pregnant women except in clinical circumstances where no alternative therapy is appropriate.Myasthenia Gravis: Exacerbation of myasthenia gravis can occur with this pack since it has been reported in patients receiving clarithromycin tablets.
মিথস্ক্রিয়া
Triple therapy regimen should be used with caution when co-administrated with following drugs: Tacrolimus, cyclosporine, clopidogrel, citalopram, cilostazol, probenecid, allopurinol, itraconazole, ketoconazole, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, saquinavir, ritonavir, etravirine, rilpivirine-containing products, atazanavir, nelfinavir.
গর্ভাবস্থাকালীন ব্যবহার
Based on findings from animal studies and observational studies in pregnant women with use of clarithromycin, use of this triple pack is not recommended in pregnant women except in clinical circumstances where no alternative therapy is appropriate. There are no data regarding the presence of vonoprazan in human milk, the effects on the breastfed infant or the effects on milk production. Vonoprazan and its metabolites are present in rat milk.
বৈপরীত্য
The standard triple therapy regimen is contraindicated in patients with known hypersensitivity to vonoprazan, amoxicillin or any other betalactams, clarithromycin or any other macrolide antimicrobials
অতিরিক্ত সতর্কতা
তীব্র ওভারডোজ
If overdose occurs, should consult with doctor immediately.
অন্যান্য ওষুধের সাথে প্রতিক্রিয়া
সংরক্ষণ
Do not store above 30°C. Keep in a dry place. Protect from light and keep out of the reach of children.
